Arthritis as an initial presentation of malignancy: two case reports

Abstract Background Arthritis is rarely reported as a paraneoplastic manifestation of occult malignancy. We report herein two cases arthritis due to Case 1 The patient was 65-year-old woman asian descent who former smoker with history spine surgery performed for L4/L5 degenerative disc disease. She presented 1-month oligoarthritis affecting both ankle joints and early morning stiffness about 3 hours. Laboratory tests were positive antinuclear antibody at titer 1:320 (speckled) but negative rheumatoid factor. treated seronegative spondyloarthritis started on prednisolone without much improvement. A routine chest radiograph incidentally revealed right lung mass which found be adenocarcinoma the lung. gefitinib her resolved. 2 64-year-old descent, nonsmoker, chief complaint asymmetrical polyarthritis involving wrist, second third metacarpophalangeal joints, first fifth proximal interphalangeal joints. (RA) sulfasalazine, poor clinical response. Six months later, she developed abdominal pain diagnosed ovarian carcinoma by laparotomy. Her resolved following treatment malignancy chemotherapy. Conclusion In summary, usually presents in an atypical manner responds poorly disease-modifying antirheumatic drugs. Accordingly, we recommend screening patients presenting arthritis.